P1246A new approach to intra- and early postoperative glycemic control in patients with IHD and diabetes mellitus type 2 undergoing CABG

Objectives: The aim of our study was to assess the continuous glucose monitoring (CGMS) efficacy in association with insulin pump therapy in patients with IHD and diabetes mellitus type 2 (DM2) undergoing CABG in intra- and early postoperative periods. Methods: The study involved 86 patients (mean age 62+6, 6 years) undergoing isolated CABG in our center between April 2016 and November 2017. Patients were divided into two groups: 39 patients with DM2 and 47 patients without DM2. In both groups of patients we used CGMS in intra- and early postoperative periods (72 hours). Moreover, in patients with severe DM2 CGMS was associated with insulin pump therapy (MiniMed Paradigm Veo 554/754) to successful intra- and postoperative glucose controlling. Blood samples were taken before surgery, and then at one hour, 12 hours, 7 days, and 1 year after the operation. Besides commonly used tests (such as HbA1C, CRP, etc.), we analyzed asymmetric dimethylarginine (ADMA), leptin and adiponectin levels in order to estimate their prognostic value.