Abstract 18978: Fractional Flow Reserve Derived From Coronary Computed Tomography Safely Defers Invasive Coronary Angiography in Patients With Stable Coronary Artery Disease

Introduction: Fractional flow reserve (FFR) derived from coronary computed tomography datasets (FFRCT) has excellent accuracy to diagnose hemodynamically significant coronary artery disease (CAD) compared to invasive FFR as the reference standard. The recent PLATFORM Trial demonstrated that the use of FFRCT resulted in the safe cancellation of 61% of invasive coronary angiograms (ICA). In the United States, the real world feasibility of a diagnostic strategy using FFRCT is unknown. Thus, we sought to determine whether the use of a coronary computed tomography angiogram (CT) plus FFRCT guided strategy as compared to CT alone will reduce the rate of unnecessary ICA without increasing the occurrence of major cardiac events. Hypothesis: A combined CT/FFRCT guided diagnostic strategy will safely reduce the number of ICA compared to CT alone. Methods: 138 consecutive patients with suspected CAD referred for CT / FFRCT over a 9-month period without known CAD at Loyola University Chicago were included in the anal...