Клітинна адгезія: види, механізми, роль у функціонуванні живих систем

Current understanding of cell adhesion, its molecular mechanisms and significance are being considered.Cell adhesion molecules (CAMs) (integrins, cadherins, selectins, mucin, immunoglobulin superfamily)and its role in tissue formation, development of tumoral processes, immune and inflammatory reactionswere described. There are two types of adhesion: cell-matrix and cell-cell adhesions. Receptors of mostfamilies CAMs involve in the adhesion at both types of interactions. According to most researchers,adhesion occurs in two stages. The first (non-specific) stage is made by physico-chemical factors. Thespecific interaction between adhesives and cell or matrix receptor at the molecular level occurs at thesecond adhesion stage. Complexes formed by cell adhesion receptors are not static, but are dynamic unitscapable of obtaining and incorporating extracellular environmental signals, and are indeed the foundationof two-way signaling between the cell and its environment. Adhesive properties are critical for start andmaintaince of three-dimensional structure and normal tissue function.