2018•Journal of Pharmacology and PharmacotherapeuticsOpen access

Efficacy and Safety of Nadifloxacin and Benzoyl Peroxide versus Adapalene and Benzoyl Peroxide in Acne Vulgaris: A Randomized Open-label Phase IV Clinical Trial

Arijit Ghosh, Kapildev Das

Abstract

Objective: To compare the efficacy and safety of nadifloxacin and benzoyl peroxide versus adapalene and benzoyl peroxide in acne vulgaris. Materials and Methods: Patients fulfilling the inclusion criteria were divided into two groups. Patients in Group A received nadifloxacin and benzoyl peroxide. Patients in Group B received adapalene and benzoyl peroxide. Duration of treatment was 12 weeks. Changes in noninflammatory lesion count (NILC), inflammatory lesion count (ILC), total lesion count (TLC), investigator global assessment score (IGA) score, and Cardiff acne disability index (CADI) score was determined at weeks 0, 4, 8, and 12. Results: Combination of adapalene and benzoyl peroxide significantly decreased NILC, ILC, TLC, IGA score, and CADI score compared to the combination of nadifloxacin and benzoyl peroxide in acne vulgaris. Conclusion: Combination of adapalene and benzoyl peroxide is significantly more effective compared to the combination of nadifloxacin and benzoyl peroxide in the treatment of acne vulgaris.

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Key concepts: Benzoyl peroxide, Adapalene, Acne, Medicine, Dermatology, Chemistry, Organic chemistry, Polymer