1990•Journal of Ayub Medical College AbbottabadOpen access

A COMPARATIVE STUDY OF THE EFFECT OF ACETYLCHOLINE AND PROSTAGLANDIN F2a ON ISOLATED TRACHEALIS MUSCLE OF GUINEA *PIG

Shah Nawaz, Maj. Kamran, Qazi Rashid Ahmad, Abdul Rashid

Abstract

Abstract : Acetylcholine and prostaglandin F 2a , both produce constriction of the broncheal smooth muscle. In present study, the bronchoconstricting effect of both these drugs was compared by utilizing the isolated trachea of guinea-pig as experimental tissue. Results of the present study have shown that acetylcholine produces more powerful constriction of the isolated trachea of the guinea-pig. At high concentrations, the effect of acetylcholine was more poten than that of prostaglandin F 2a . But in low concentrations, the bronchoconstricting effect of both the drugs was almost similar.

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Key concepts: Trachealis muscle, Acetylcholine, Medicine, Guinea pig, Prostaglandin, Constriction, Smooth muscle, Histamine