2018•Journal of Drug Delivery and TherapeuticsOpen access

Wound healing promoting activity of Earthworm, Eutyphoeus gammiei (Beddard): in vitro studies on human skin keratinocyte cell line (HaCat).

Susmita Saha, Deepjyoti Bhattacharjee, Anwesha Saha, Gahin De, Partha Sarathi Saha, Samir Kumar Sil

Abstract

Earthworm, Eutyphoeus gammiei, homogenate (EGH) was screened for wound healing activity on human keratinocyte cell line, HaCat, by cell proliferation and migration assays. The maximum proliferation and migration of keratinocyte cells were observed at the dose of 25μg/ml. As cell proliferation and migration are key factors for wound healing, the study clearly suggests the potential role of earthworm species Eutyphoeus gammiei on wound healing. Keywords: Eutyphoeus gammiei, Keratinocyte, MTT assay, scratch assay.

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Available abstract

Key concepts: HaCaT, Keratinocyte, Wound healing, Cell culture, MTT assay, Cell growth, In vitro, Cell migration