2018•International Journal Of Medical Science And Clinical InventionOpen access

Denosumab-related osteonecrosis of the jaw in a patient with osteoporosis: case report

Zornitsa Mihaylova, 1431 Sofia, 1 G. Sofiyski str., Evgeniy Aleksiev, Radomir Ugrinov

Abstract

We report a case of osteonecrosis of the jaw (ONJ) associated with denosumab therapy in a 69-year-old female patient being treated for osteoporosis.The patient was admitted in Oral and maxillofacial surgery clinic twice because of nonhealing extraction wounds and inflammatory complications.We recommend conservative therapeutic approach and avoidance of extensive surgery in patients with ONJ.

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Key concepts: Medicine, Denosumab, Osteonecrosis of the jaw, Osteoporosis, Jaw Fracture, Dentistry, Internal medicine, Bisphosphonate