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2018•Yearbook of pediatric endocrinologyRequires access

Klotho expression in osteocytes regulates bone metabolism and controls bone formation

Hirotaka Komaba, Jovana Kaludjerovic, Hu Dz, Kenichi Nagano, Katsuhiko Amano, Nicole Ide, Tadatoshi Sato, Michael Densmore, Hanai Ji, Hannes Olauson, Teresita Bellido, TE Larsson, Roland Baron, Beate Lanske

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Abstract

Klotho was originally identified as a senescence-related protein because mice carrying hypomorphic Klotho alleles (kl/kl) develop premature aging with low bone turnover and osteoporosis. Primary function of Klotho is to form a specific receptor complex with fibroblast growth factor (FGF) receptor 1 (FGFR1) through which it mediates the biological function of FGF23, which in the kidney inhibits renal phosphate reabsorption and suppresses 1,25-dihydroxyvitamin D [1,25(OH)2D] synthesis. In chronic kidney disease, circulating FGF23 levels increase as a compensatory response to maintain a normal phosphate balance. High FGF23 in end-stage kidney disease exerts toxic effects on the cardiovascular and immune systems in a Klotho-independent manner.

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What this paper is about

Klotho was originally identified as a senescence-related protein because mice carrying hypomorphic Klotho alleles (kl/kl) develop premature aging with low bone turnover and osteoporosis. Primary function of Klotho is to form a specific receptor complex with fibroblast growth factor (FGF) receptor 1 (FGFR1) through which it mediates the biological function of FGF23, which in the kidney inhibits renal phosphate reabsorption and suppresses 1,25-dihydroxyvitamin D [1,25(OH)2D] synthesis. In chronic kidney disease, circulating FGF23 levels increase as a compensatory response to maintain a normal phosphate balance. High FGF23 in end-stage kidney disease exerts toxic effects on the cardiovascular and immune systems in a Klotho-independent manner.

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Available abstract

Klotho was originally identified as a senescence-related protein because mice carrying hypomorphic Klotho alleles (kl/kl) develop premature aging with low bone turnover and osteoporosis. Primary function of Klotho is to form a specific receptor complex with fibroblast growth factor (FGF) receptor 1 (FGFR1) through which it mediates the biological function of FGF23, which in the kidney inhibits renal phosphate reabsorption and suppresses 1,25-dihydroxyvitamin D [1,25(OH)2D] synthesis. In chronic kidney disease, circulating FGF23 levels increase as a compensatory response to maintain a normal phosphate balance. High FGF23 in end-stage kidney disease exerts toxic effects on the cardiovascular and immune systems in a Klotho-independent manner.

Key concepts: Klotho, Endocrinology, Fibroblast growth factor 23, Internal medicine, Bone remodeling, Fibroblast growth factor, Kidney, Receptor

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