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2008•OUKA (Osaka University Knowledge Archive) (Osaka University)Open access

IMMOBILIZED-LIPOSOME SENSOR SYSTEM FOR DETECTION OF DAMAGED PROTEINS

Ryoichi Kuboi, Hiroshi Umakoshi, Toshinori Shimanouchi, Hideaki Ishii, Thi Vu Huong, Shin‐ya Morita

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Abstract

An electrolyte-entrapping liposome was immobilized on an Au electrode to design and develop of an immobilized liposome sensor (ILS) system for the detection of the damaged proteins.Three proteins (bovine carbonic anhydrase, lysozyme and chitosanase) were used as model proteins.Damaged proteins could be effectively detected by a chronoamperometric method due to the protein-liposome interactions.The ILS system can be a useful tool for an on-line monitoring to not only conformational changes of proteins but also a bioprocess.

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An electrolyte-entrapping liposome was immobilized on an Au electrode to design and develop of an immobilized liposome sensor (ILS) system for the detection of the damaged proteins.Three proteins (bovine carbonic anhydrase, lysozyme and chitosanase) were used as model proteins.Damaged proteins could be effectively detected by a chronoamperometric method due to the protein-liposome interactions.The ILS system can be a useful tool for an on-line monitoring to not only conformational changes of proteins but also a bioprocess.

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Available abstract

An electrolyte-entrapping liposome was immobilized on an Au electrode to design and develop of an immobilized liposome sensor (ILS) system for the detection of the damaged proteins.Three proteins (bovine carbonic anhydrase, lysozyme and chitosanase) were used as model proteins.Damaged proteins could be effectively detected by a chronoamperometric method due to the protein-liposome interactions.The ILS system can be a useful tool for an on-line monitoring to not only conformational changes of proteins but also a bioprocess.

Key concepts: Liposome, Chemistry, Computer science, Biochemistry

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