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2014•STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)Requires access

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment

Sirpa Loukovaara, Kaisa Lehti, Alexandra Robciuc, Timo Pessi, Juha M. Holopainen, Katri M. Koli, Ilkka J. R. Immonen, Jorma Keski‐Oja

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Abstract

Purpose To explore factors related to pathogenesis of rhegmatogenous retinal detachment (RRD) and development of proliferative vitreoretinopathy (PVR), vitreous levels of angiopoietin-1 and −2 (Ang-1 and −2), previously undefined in RRD, transforming growth factor-(TGF) β1, vascular endothelial growth factor (VEGF), erythropoietin (EPO) and proteolytic mediators of extracellular matrix remodelling (MMP-2 and −9) were compared in eyes with RRD and eyes with idiopathic macular hole or pucker.

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What this paper is about

Purpose To explore factors related to pathogenesis of rhegmatogenous retinal detachment (RRD) and development of proliferative vitreoretinopathy (PVR), vitreous levels of angiopoietin-1 and −2 (Ang-1 and −2), previously undefined in RRD, transforming growth factor-(TGF) β1, vascular endothelial growth factor (VEGF), erythropoietin (EPO) and proteolytic mediators of extracellular matrix remodelling (MMP-2 and −9) were compared in eyes with RRD and eyes with idiopathic macular hole or pucker.

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Available abstract

Purpose To explore factors related to pathogenesis of rhegmatogenous retinal detachment (RRD) and development of proliferative vitreoretinopathy (PVR), vitreous levels of angiopoietin-1 and −2 (Ang-1 and −2), previously undefined in RRD, transforming growth factor-(TGF) β1, vascular endothelial growth factor (VEGF), erythropoietin (EPO) and proteolytic mediators of extracellular matrix remodelling (MMP-2 and −9) were compared in eyes with RRD and eyes with idiopathic macular hole or pucker.

Key concepts: Proliferative vitreoretinopathy, Retinal detachment, Ophthalmology, Angiopoietin, Extracellular matrix, Medicine, Vascular endothelial growth factor, Pathogenesis

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