2000•Proceedings of The 4th International Electronic Conference on Synthetic Organic ChemistryOpen access

Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers

Györgyi Kovács, Zoltán Tímár, Zoltán Kele, Lajos Kovács

Abstract

The optimization of peptide nucleic acid (PNA) oligomer synthesis was carried out using Fmoc/acyl-protected monomers on NovaSyn® hydroxy-Tentagel resin and HATU/DIPEA/lutidine activation. The sequences H-Leu-ttttt- Gly-NH2 (1) and H-Gly-cgg-act-aag-tcc-att-gc-Gly-NH2 (2) were prepared and characterized by electrospray mass spectrometry

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Available abstract

Key concepts: Oligomer, Monomer, Peptide nucleic acid, Nucleic acid, Chemistry, Peptide, Peptide synthesis, Mass spectrometry