EFFECT OF ETHANOL EXTRACT LEAF BUASBUAS (PREMNA PUBESCENS. BLUME) TO DECREASE BLOOD SUGAR LEVELS IN RATS MALE (RATTUS NORVEGICUS) THE INDUCED ALLOXAN

This study aimed to analyze the effect of ethanol extract of leaves Buasbuas (Premnapubescens. Blume) / EEP to (i) a decrease in blood sugar levels (KGD), and (ii) the increase in body weight (BW) in rats with diabetes mellitus (DM). This type of research is experimentally using completely randomized design (CRD) non factorial using 20 head of white male rats (Rattusnorvegicus) Wistar were divided into five groups: (i) negative control / non diabetes mellitus (KN), (ii) positive control (KD), (iii) control drug / group of non DM by EEP 200 mg / kg (KE), (iv) diabetic group by EEP 200 mg / kg (P2), and (v) diabetic group by EEP 300 mg / kg (P3). DM \nconditions obtained by alloxan induction dose of 150 mg / kg were injected intraperitoneally. KGD measurement. Then, DM rats (except KD) EEP given every other day for 28 days orally using a needle probe. Making extract \nusing maceration method with 96% ethanol. KGD measurement and BB performed every four days in the morning. Data KGD and BB were analyzed using one-way ANOVA followed by Tukey's test using SPSS 21.0. Results showed EEP dose of 200 mg / kg body weight to lower and raise the BB KGD significantly (P <0.05), but the EEP dose of 300 mg / kg did not give effect to a decrease or increase in BB rats KGD DM. EEP Award dose of 200 mg / kg in mice does not give effect to the KGD or BB.