Genetic Analysis for Prenatal Diagnosis via Amniocentesis at Vietnam National Hospital of Obstetrics and Gyneacology from 2012 to 2016

The study aimed at genetic analysis of amniocentesis (karyotypes) for prenatal diagnosis. Methodology: this is a retrospective study among pregnant women indicated for amniocentesis and consent to the study. 11,463 cases were included to the study during 5 years’ period from 2012 to 2016. Results: The rate of successful karyotyping was 99.9%, 10 cases (0.1%) were failure to obtain karyotype. The complication of amniocentesis was miscarriage (0.05%). Acceptance rates for amniocentesis in total number of deliveries were 10.7%, and indications for amniocentesis were mainly high-risk pregnancy such as advanced maternal age, increased nuchal transluciency and abnormalities were observed by ultrasonography. Chromosomal abnormalities are 6.7%, popular conditions were found including trisomy 21(40.6%), trisomy 18 (13.8%), trisomy 13 (2.1%), 45, XO (1.9%). Conclusion: Obtaining fetal fraction by amniocentesis is completely feasible, has great efficacy, safety and helps making decision on the fate of pregnancy.