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2018•Nature Chemical BiologyOpen access

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma T. van der Westhuizen, Jacob P. Mahoney, João Gabriel Sicupira Rodrigues, Thomas J. Mildorf, Ron O. Dror, David Elliot Shaw, Michel Bouvier, Els Pardon, Jan Steyaert, Roger K. Sunahara, William I. Weis, Cheng Zhang, Brian K. Kobilka

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Key concepts: Partial agonist, Salmeterol, Agonist, G protein-coupled receptor, Chemistry, Receptor, Mutagenesis, Pharmacology

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