Histopathological study of Uterine Leiomyoma in Hysterectomy Specimens

Background: Uterine leiomyoma is the most common benign neoplasm in women of reproductive age group. Hysterectomy is a mode of therapy in uterine Leiomyoma. The objective of this study was to evaluate the histopathological changes in hysterectomy specimens with uterine leiomyomas.METHODS: This is a retrospective study of one hundred sixty eight patients who underwent hysterectomy for uterine leiomyoma.Results: Uterine leiomyoma was most common in the age group of 41-50 years (54.76%). Most common location of leiomyoma was intramural (51.2%). Degenerative changes were seen in 10.72% cases. Hyaline degeneration was the most common type of degeneration (7.14%). Proliferative endometrium was the most common endometrial pattern (63.1%) in uterine leiomyoma. Associated malignant lesions were observed in 1.8 % cases of uterine leiomyoma.CONCLUSION: Uterine leiomyoma is associated with degenerative changes and coexistent benign and malignant patholologies. Histopathological examination of hysterectomy specimens should be done to confirm the diagnosis and rule out other pathologies, especially malignant lesions.