A Study of Lipid Profile in Chronic Kidney Disease Patients on Conservative Management, Haemodialysis and After Renal Transplantation

BACKGROUND: Chronic kidney disease [CKD] is associated with specific abnormalities in the lipoprotein metabolism both in the early and in the advanced stages of chronic renal failure. Regardless of age, heart disease is a major cause of morbidity and mortality among patients with renal failure. Our study aimed at to estimate lipid profile in CKD patients on conservative management, on haemodialysis, after renal transplantation and to compare with healthy controls. METHODS: The study population was 60 patients with 20 patients in each group and 20 healthy controls. Each group had 10 males and 10 females without diabetes or hypertension. After 12 hrs fasting serum lipid profile was estimated in all groups. RESULTS: The mean total cholesterol was within optimal level in all the three groups. The mean triglyceride was borderline high in conservative and haemodialysis group, whereas in post transplant group it was high as per ATP III guidelines. The mean LDL was optimal in conservative and hemodialysis group, high in post transplant group. The mean HDL was decreased in all the three groups. Total cholesterol /HDL ratio was increased in all the three groups. CONCLUSION: From this study it is inferred that dyslipidemia is more common chronic kidney disease patients and more marked in renal transplant recipients.