2016•CirculationRequires access

Abstract 17161: Inflammatory Serine Protease Inhibition Attenuates Myocyte Apoptosis and Cardiac Dysfunction via Intervention of Peroxisome Proliferator-activated Receptor Gamma-induced Lipotoxicity and Inflammation in High Fat Diet-induced Diabetic Cardiomyopathy

Kunal Sikder, Amrita Sarkar, Sanket K. Shukla, Aimee Abbott, Domenica Carrier, Carlos Barbery, Richard G. Pestell, Khadija Rafiq

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Abstract

Background: Diet consisting of high percentage of fat induces lipotoxicity, leading to type II diabetes and diabetic cardiomyopathy (DCM). The mechanism by which high fat diet (HFD) mediated lipoto...

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Key concepts: Lipotoxicity, Medicine, Diabetic cardiomyopathy, Inflammation, Internal medicine, Cardiomyopathy, Endocrinology, Apoptosis