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2018•Journal of Visualized ExperimentsOpen access

Transcranial Direct Current Stimulation (tDCS) in Mice

Eduardo de Souza Nicolau, Kevin Augusto Farias de Alvarenga, Hèlia Tenza‐Ferrer, Matheus Carvalho Alves Nogueira, Fernanda Donizete Rezende, Nycolle Ferreira Nicolau, Mélcar Collodetti, Débora Marques de Miranda, Luiz Alexandre Viana Magno, Marco Aurélio Romano‐Silva

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Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.

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What this paper is about

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.

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Available abstract

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.

Key concepts: Transcranial direct-current stimulation, Neuromodulation, Neuroscience, Brain stimulation, Stimulation, Medicine, Psychology

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