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2018•Open Forum Infectious DiseasesOpen access

Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children

Kathleen Chiotos, Pranita D. Tamma, Kelly B. Flett, Manjiree Karandikar, Koorosh Nemati, Warren B. Bilker, Theoklis E. Zaoutis, Jennifer Han

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Abstract

In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

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What this paper is about

In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

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OpenAlex reports 51 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

Key concepts: Carbapenem-resistant enterobacteriaceae, Enterobacteriaceae, Medicine, Carbapenem, Antibiotics, Pediatrics, Enterobacteriaceae Infections, Internal medicine

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