2018•Investigational New DrugsOpen access

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Lisa M. Oppegard, Justine L. Delgado, Chaitanya A. Kulkarni, Tyrell R. Towle, Delaney E. Hart, Bridget P. Williams, Sarah R.C. Lentz, Beverly Norris, Craig M. Flory, Robert J. Schumacher, Daryl J. Murry, Robert J. Kerns, Hiroshi Hiasa

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Key concepts: Topoisomerase, DNA gyrase, Topoisomerase IV, Topoisomerase inhibitor, In vivo, Cell culture, DNA, Chemistry