2018•Antimicrobial Agents and ChemotherapyOpen access
Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients
Lois W. Martin, Cynthia L. Robson, Annabelle M. Watts, Andrew Robert Gray, Claire Elizabeth Wainwright, Scott Cameron Bell, Kay A. Ramsay, Timothy J. Kidd, David W. Reid, Ben Brockway, Iain L. Lamont
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Abstract
The lungs of individuals with cystic fibrosis (CF) become chronically infected with Pseudomonas aeruginosa that is difficult to eradicate by antibiotic treatment. Two key P. aeruginosa antibiotic resistance mechanisms are the AmpC β-lactamase that degrades β-lactam antibiotics and MexXYOprM, a three-protein efflux pump that expels aminoglycoside antibiotics from the bacterial cells.