2018•European Heart JournalRequires access
3284Impact of noninvasive fractional flow reserve derived from coronary computed tomography angiography for prognosis in patients with suspected stable coronary artery disease
Y. Sobue, Hitoshi Matsuo, Yoshiaki Kawase, Takeshi Kondo, Toru Tanigaki, Shuichi Okamoto, Hiroyuki Omori, Tetsuya Hirata, Jun Kikuchi, Hideaki Ota, Taiji Miyake, Itta Kawamura, H. Kamiya, Kazuhiro Tsuchiya, Takahiko Suzuki
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Abstract
Introduction: FFR measured during invasive coronary angiography is the corner stone for assessment of myocardial ischemia in patients with suspected stable coronary artery disease (CAD). Recently, FFR derived from standard acquired coronary computed tomography angiography (FFR-CT) have been introduced as noninvasive tool for detection of myocardial ischemia. However, little is well known on assessment of prognosis by FFR-CT in those patients. Therefore, we prospectively assessed the prognosis with FFR-CT. Methods and results: We enrolled 637 consecutive patients, who underwent computed tomography angiography due to suspected CAD between August 2015 and October 2017. FFR-CT was blindly analyzed by an independent core laboratory. The endpoint was a composite of death from any cause, nonfatal myocardial infarction or nonfatal stroke and revascularization. During the follow-up period of 11±6 months, 152 (23.9%) patients had developed the endpoint. In the multivariate Cox analyses, FFR-CT <0.70 was independent risk predictor of MACE in patients with CAD (HR 7.42, 95% CI 4.97–11.1, P<0.01).