2018•Chemical ScienceOpen access

A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

Yong‐Kyun Sim, Hee‐Tae Jung, Su Hyun Kim, Jung‐Woo Park, Woo-Jin Park, Chul‐Ho Jun

Abstract

A simple, one-step method for covalent bond immobilization of biomolecules on silica operated in water is described. In the approach, an NHS-ester linked methallylsilane is utilized as a bifunctional linker to couple the biomolecule to the silica surface. Weak organic acid such as acetic acid activates the silica surface enough to react with bifunctional linker without destroying activity of biomolecule.

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Key concepts: Biomolecule, Covalent bond, Aqueous solution, Chemistry, Bond, Combinatorial chemistry, Nanotechnology, Materials science