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2018•The African Journal of Pharmacology and TherapeuticsRequires access

Antiulcerogenic activity of husk extract of Zea mays

Jude Efiom Okokon, Jackson Obot, Louis U Amazu

Open publisher page 2 citations

Abstract

Background: Zea mays husk is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer. Objective: To investigate the antiulcerogenic potential of husk extract of Zea mays . Methods: Ethanol husk extract of Zea mays (187-784 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats. Results: The husk extract was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion. Conclusion: These results suggest that the husk extract of Zea mays possess antiulcerogenic potentials which are due to the activities of the phytochemical constituents. Keywords : Zea mays , husk, antiulcer, gastrointestinal system.

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What this paper is about

Background: Zea mays husk is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer. Objective: To investigate the antiulcerogenic potential of husk extract of Zea mays . Methods: Ethanol husk extract of Zea mays (187-784 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats. Results: The husk extract was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion. Conclusion: These results suggest that the husk extract of Zea mays possess antiulcerogenic potentials which are due to the activities of the phytochemical constituents. Keywords : Zea mays , husk, antiulcer, gastrointestinal system.

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Available abstract

Background: Zea mays husk is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer. Objective: To investigate the antiulcerogenic potential of husk extract of Zea mays . Methods: Ethanol husk extract of Zea mays (187-784 mg/kg) was evaluated for antiulcerogenic activity against indomethacin, ethanol and histamine-induced ulcers in rats. Results: The husk extract was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion. Conclusion: These results suggest that the husk extract of Zea mays possess antiulcerogenic potentials which are due to the activities of the phytochemical constituents. Keywords : Zea mays , husk, antiulcer, gastrointestinal system.

Key concepts: Husk, Zea mays, Phytochemical, Histamine, Traditional medicine, Ethanol, Chemistry, Medicine

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