Optically active N -alkyl aziridines via stereospecific reductive cyclization of α-mesylated acetamides

An efficient method for the synthesis of optically active N -alkyl aziridines has been realized for the first time by stereospecific reductive cyclization of optically active α-mesylated acetamides. A series of optically active N -alkyl aziridines are prepared in moderate to good yields and excellent ees.