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2018•Blood AdvancesOpen access

TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice

Christopher W. Smith, Zaher Raslan, Lola Parfitt, Abdullah O. Khan, Pushpa Patel, Yotis A. Senis, Alexandra Mazharian

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Abstract

Key Points Platelet activation in vitro results in a more rapid and greater upregulation of TLT-1 surface expression compared with P-selectin. TLT-1 is more rapidly translocated to the surface of activated platelets than P-selectin during thrombus formation in vivo.

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Key Points Platelet activation in vitro results in a more rapid and greater upregulation of TLT-1 surface expression compared with P-selectin. TLT-1 is more rapidly translocated to the surface of activated platelets than P-selectin during thrombus formation in vivo.

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Available abstract

Key Points Platelet activation in vitro results in a more rapid and greater upregulation of TLT-1 surface expression compared with P-selectin. TLT-1 is more rapidly translocated to the surface of activated platelets than P-selectin during thrombus formation in vivo.

Key concepts: Downregulation and upregulation, Platelet activation, P-selectin, Platelet, In vitro, In vivo, Thrombus, Cell biology

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