Clinicopathological,Histomorphological andImmunohistochemical Study of Neuroendocrine Tumors of Git.

Neuroendocrine Tumors Are Relatively Uncommon Epithelial Neoplasms With Predominant Neuroendocrine Differentiation. They Arise From Most Of The Organs In The Body. Some Of The Clinicopathological Features Of These Neuroendocrine Neoplasms Are Characteristic Of The Site Of Origin, While Other Characteristics Are Irrespective Of Their Anatomic Site. Studies On Neuroendocrine Tumors Have Concentrated On Tumors Of Specific Organ Systems Such As Gastrointestinal Tract, Pancreas And Lungs. Neuroendocrine Tumors Can Arise Anywhere In The Gastrointestinal Tract. But In The GIT, Neuroendocrine Tumors Are Predominantly Derived From The Kulchitsky’s Cells Or Enterochromaffin Cells. They Present With Different Pathologic Findings That Corresponds To The Site Of Origin And Hormone Secreting Ability Of These Tumors.46 Gastrointestinal Tract Is The Most Common Site To Be Affected.16 The Incidence Of Neuroendocrine Tumors Of GIT Is Around 67.5% Among All Neuroendocrine Tumors.53 These Tumors Develop Throughout The Gastrointestinal Tract From Oesophagus To Anus Although They Are Unusual In The Oesophagus And Anus. Small Intestine Is The Most Common Site Of Occurrence Of Neuroendocrine Tumors In The Git.30 But Most Of The Recent Studies Are Against This Concept. The Pattern Of Neuroendocrine Tumors Of Git Has Changed Over The Last Few Years. The Prognosis Of Neuroendocrine Tumors Varies According To The Grade Of The Tumor And Is Distinctly Different From Other Types Of Malignancies That Occur In GIT. The Prognosis Of Neuroendocrine Tumors Is Better Than Adenocarcinomas Of The GIT. By Histopathological Evaluation And Classification They Are Grouped Into Different Prognostic Categories According To Their Grade. Histopathological Diagnosis, Tumor Classification And Identification Of Histogenesis Of Metastases Of Unknown Or Uncertain Primary Tumors Are Considered To Be The Most Important Responsibilities Of Practical Histopathologists. At Present, In Addition To The Traditional Light Microscopy, There Is A List Of Other Informative Methods That Support Histopathologists In Their Work Such As Electron Microscopy, Histochemistry, Immunohistochemistry And Molecular Methods. In The Past 20 Years, Immunohistochemistry Has Dramatically Developed And Has Become A Very Powerful And Simple Tool In Diagnostic Histopathology. Many Steps Of Immune-Stain Protocols Were Markedly Simplified And A Large Number Of Diagnostic Antibodies Were Introduced To Resolve Many Diagnostic Problems And To Increase The Diagnostic Accuracy. As The Size Of The Biopsies Decrease, The Role Of Immunohistochemical Stains Will Become Even More Important In Determining The Origin And Differentiation Of Gastrointestinal Tract Tumors. Immunohistochemical Stains Such As Neuron Specific Enolase, Chromogranin And Synaptophysin Are Commonly Used To Identify Neuroendocrine Tumors.37 In This Study We Analyse The Clinicopathological, Histomorphological And Immunohistochemical Study Of Neuroendocrine Tumors Of Gastrointestinal Tract.