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2018•Infection and ImmunityOpen access

Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells

Christopher C. Phelps, Stephen Vadia, Eusondia Arnett, Yubo Tan, Xiaoli Zhang, Sarika Pathak-Sharma, Mikhail A. Gavrilin, Stéphanie Seveau

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Abstract

Listeria monocytogenes is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to promote bacterial uptake by host cells, and the secreted pore-forming toxin listeriolysin O (LLO), which disrupts the phagosome to allow bacterial proliferation in the cytosol.

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What this paper is about

Listeria monocytogenes is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to promote bacterial uptake by host cells, and the secreted pore-forming toxin listeriolysin O (LLO), which disrupts the phagosome to allow bacterial proliferation in the cytosol.

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OpenAlex reports 77 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Listeria monocytogenes is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to promote bacterial uptake by host cells, and the secreted pore-forming toxin listeriolysin O (LLO), which disrupts the phagosome to allow bacterial proliferation in the cytosol.

Key concepts: Listeriolysin O, Listeria monocytogenes, Microbiology, Biology, Virulence, Phagosome, Intracellular parasite, Cytolysin

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Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells — Research Paper | ScholarLens