Efficacy and safety of different regimens of fixed combination of perindopril 10 mg/indapamide 2.5 mg in patients with arterial hypertension

Objective: The most common strategy to improve blood pressure (BP) control is improving compliance with once daily administration of antihypertensive therapy. Aim: To assess the efficacy, tolerability, safety of different regimes of prescription of combination of perindopril 10 mg and indapamide 2.5 mg.Design and methods. We included 31 patients (56±9.3 years, BMI 30.5±5.3 kg/m2, duration of arterial hypertension - 7.1±5.8 years), on two-component therapy (except combination of perindopril and indapamide) with BP>140/90 mmHg. At baseline ambulatory blood pressure monitoring (ABPM), blood tests were performed in 20 men and 10 women, then, patients were randomized into two groups: morning and evening regimes. Previous therapy was canceled and prescribed a combination of perindopril 10 mg and indapamide 2.5 mg. After 8 weeks of treatment, ABPM and blood tests were re-conducted. Results. Baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the whole group - 148.4±10.0/95.6±10.7 mm Hg. After 1 and 2 months of treatment Noliprel-A bi-forte SBP/DBP decreased to 131.4±8.4/86.6±5.7 mm Hg and to 133.4±11.2/84.5±8.8 mm Hg respectively. ( p <0.001 vs baseline). No additional antihypertensive drugs were added. The combination of perindopril 10 mg and indapamide 2.5 mg effectively reduces BP by ABPM data. There was no difference in terms of BP in morning and evening regime groups. Statistically significant changes in blood indices were not detected. Tolerability was assessed by The combination of perindopril 10 mg and indapamide 2.5 mg effectively reduces BP by ABPM data. There was no difference in terms of BP in morning and evening regime groups. Statistically significant changes in blood indices were not detected. Tolerability was assessed by patients as good to very good.Conclusion. The combination of 10 mg perindopril and indapamide 2.5 mg is effective in achieving and maintaining a target BP levels. The dosing regimen does not affect the efficacy and tolerability and does not cause additional adverse effects when administered in the evening.