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2018•International Journal of Infectious DiseasesOpen access

Enterobacteriaceae with dissociated resistance phenotype to third generation cephalosporins: in vitro response to ceftazidime and cefepime

Karen Liebrenz, Martín Marchisio, Emilce Méndez, José Di Conza

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Abstract

Background: β-lactamases are the main mechanism of resistance to β-lactam antibiotics in gram-negative bacilli. Two relevant groups of these enzymes are the extended spectrum β-lactamases (ESBL) and plasmid mediated AmpC enzymes (pAmpC). CLSI and EUCAST mentioned that they should be reported as tested and the presence or absence of an ESBL (or pAmpC) does not in itself influence the categorization of susceptibility.

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Background: β-lactamases are the main mechanism of resistance to β-lactam antibiotics in gram-negative bacilli. Two relevant groups of these enzymes are the extended spectrum β-lactamases (ESBL) and plasmid mediated AmpC enzymes (pAmpC). CLSI and EUCAST mentioned that they should be reported as tested and the presence or absence of an ESBL (or pAmpC) does not in itself influence the categorization of susceptibility.

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Available abstract

Background: β-lactamases are the main mechanism of resistance to β-lactam antibiotics in gram-negative bacilli. Two relevant groups of these enzymes are the extended spectrum β-lactamases (ESBL) and plasmid mediated AmpC enzymes (pAmpC). CLSI and EUCAST mentioned that they should be reported as tested and the presence or absence of an ESBL (or pAmpC) does not in itself influence the categorization of susceptibility.

Key concepts: Ceftazidime, Proteus mirabilis, Cefotaxime, Cefepime, Microbiology, Cephalosporin, Klebsiella pneumoniae, Biology

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Enterobacteriaceae with dissociated resistance phenotype to third generation cephalosporins: in vitro response to ceftazidime and cefepime — Research Paper | ScholarLens