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Zn-Catalyzed Aldol Reaction of Methyl Vinyl Ketone

B. M. Trost, S. Shin, J. A. Sclafani

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Abstract

Significance Methyl vinyl ketone (MVK) is typically base sensitive, but functions as an effective bifunctional building block for the Zn-catalyzed aldol reaction under neutral conditions. This first example of asymmetric aldol reaction using MVK works well with numerous aliphatic aldehydes, yielding products of good ee and in moderate to good yield.

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What this paper is about

Significance Methyl vinyl ketone (MVK) is typically base sensitive, but functions as an effective bifunctional building block for the Zn-catalyzed aldol reaction under neutral conditions. This first example of asymmetric aldol reaction using MVK works well with numerous aliphatic aldehydes, yielding products of good ee and in moderate to good yield.

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Available abstract

Significance Methyl vinyl ketone (MVK) is typically base sensitive, but functions as an effective bifunctional building block for the Zn-catalyzed aldol reaction under neutral conditions. This first example of asymmetric aldol reaction using MVK works well with numerous aliphatic aldehydes, yielding products of good ee and in moderate to good yield.

Key concepts: Methyl vinyl ketone, Aldol reaction, Chemistry, Bifunctional, Ketone, Catalysis, Yield (engineering), Organic chemistry

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