Antimicrobial activity of Garcinia mangostana using different solvents extracts

The present study investigates antibacterial activity of Garcinia mangostana in different solvents by disc diffusion method. Seven different extracts were prepared, using different solvents viz., methanol, ethanol, acetone, chloroform, ethyl ether, petroleum sprit and water. The result of antibacterial screening showed that all the extracts show moderate inhibition against pathogenic bacteria, both gram positive including Staphylococcus aureus, Streptococcus pyogenes, and Bacilllus subtillis and gram negative bacteria including Escherichia coli and Pseudomonas aeruginosa. Overall analysis of the antibacterial activity of tested samples revealed that the highest inhibitory activity was produced by ethanol extract (31±0.37mm) against S. pyogenes while minimal activity was found from ethyl ether extract (12 ± 0.00) against B.subtillis. Minimum inhibitory concentration (MIC) for S. pyogenes was 10 mg/ml for methanol extract.