The effect of elevated intraocular pressure on the retinal circulation in open-angle glaucoma and ocular hypertension. : A study on retinal mean transit time

Purpose of the studies was to develop a more robust technique to determine retinal mean transit time in healthy and in glaucoma eyes and to evaluate the circulation of the optic nerve head in glaucoma patients.The retinal mean transit time impulse-response method was evaluated in human healthy eyes and normal values and reproducibility were tested.Fluorescein and indocyanine green angiographies were recorded and the pictures were analyzed to obtain retinal mean transit time and to evaluate the proportion of low-fluorescent pixels of the optic nerve head in the glaucoma patients. Visual field defects were correlated to loss of neuroretinal rim area.A disturbed circulation was observed in the glaucoma patients, whether primary or secondary to loss of nerve fibre tissue can not be determined from these studies.