2014•Industrial health and Occupational DiseasesRequires access
The protective effect of vitamin C on the mutagenic toxicology of nano-titanium dioxide in mice
Yaning Wang, Guan Qiu-yan, Xie Lv, Huicai Guo, Yi Liu, Hou Yu-chun, Rong Zhang, Yujie Niu
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Abstract
Objective To observe the protective effect of vitamin C on the mutagenic toxicology of 50nm titanium dioxide in mice.Methods One hundred and fifty mice with body weight 20~26g were randomly divided into five groups:the control group,50nm TiO2group(2g/kg)and three Vitamin C +50nm TiO2 groups(100mg/kg,200mg/kg,400mg/kg,respectively).The mice were treated by intragastric administration.Chromosome aberration rate and micronucleus rate of bone marrow cells,micronucleus rate of erythrocyte,chromosome aberration rate in testicle and sperm abnormality rate were observed.Results The micronucleus rate of erythrocyte in the victamin C +50nm TiO2group at the concentration of 200and 400mg/kg was significantly decreased compared with the nano-titanium dioxide group(P<0.05).Chromosome aberration rate and micronucleus rate of bone marrow cells,chromosome aberration rate in testicle and sperm abnormality rate in the victamin C group at the different concentration were significantly decreased compared with the nano-titanium dioxide group(P<0.05).Conclusions Vitamin C antagonises the genetic toxicity induced by nano-titanium dioxide in somatic cells and germ cells of mice.