FP064ASSOCIATION BETWEEN POLYCYSTIC LIVER CYST AND KIDNEY CYST IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

INTRODUCTION AND AIMS: Polycystic liver disease(PLD) is one of the complications of autosomal dominant polycystic kidney disease(ADPKD). Severity of these complications are varies. Total liver volume is increasing after patients reached end stage of renal disease, causing abdominal compression, portal hypertension, liver cyst infection, liver dysfunction. The aim of this study is to find out the correlations between liver volume and clinical characteristics. METHODS: Cross-sectional study was conducted. Total liver volume(TLV) and total kidney volume(TKV) were calculated in a cohort of 152 out-patients with ADPKD in our hospital by using 3 dimensional calculated program from computed tomography and evaluated according to clinical and laboratory data. RESULTS: Among the study cohort, median age was 53 year old, male predominant(n=90). Median serum creatinine level was 1.03mg/dL, median TLV was 1639cm3 , median TKV was 1495cm3. Hemodialysis was conducted in nine patients. Esophageal varix was found in five patients by endoscopy. There was no correlation between TLV and TKV. From univariate linear regression analysis, low level of hemoglobin, platelet count, serum albumin, calcium, choline esterase, existence of esophageal varix, not taking tolvaptan, high level of aspartate aminotransferase, C-related protein, urine protein excretion were significantly corelate to TLV. But multivariate analysis reveals that only varix associated with TLV(p<0.01). CONCLUSIONS: Clinical factors related to liver, especially varix, were associated to TLV in ADPKD. There was no co-relation between renal factors and TLV.