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2018•Chemical ScienceOpen access

Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

Srinivasaraghavan Kannan, Gireedhar Venkatachalam, Hong Hwa Lim, Uttam Surana, Chandra Shekhar Verma

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Abstract

An oncogenic mutant-specific druggable allosteric pocket captured by MD simulations.

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An oncogenic mutant-specific druggable allosteric pocket captured by MD simulations.

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OpenAlex reports 50 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

An oncogenic mutant-specific druggable allosteric pocket captured by MD simulations.

Key concepts: Allosteric regulation, Druggability, Mutant, Epidermal growth factor receptor, Chemistry, Cell biology, Biology, Receptor

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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket — Research Paper | ScholarLens