2007•Cancer ResearchRequires access
The role of thymidylate synthase as a biomarker for pemetrexed sensitivity in lung cancer
Hiroaki Ozasa, Ken Maeno, Tetsuya Oguri, Yuji Bessho, Mikinori Miyazaki, Yuko Takano, Hiroyoshi Maeda, Shigeki Sato, Ryuzo Ueda
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Abstract
2316 Pemetrexed is promising argent for non-small cell lung cancer (NSCLC) chemotherapy; however, the biomarkers for predicting sensitivity to this argent have not been fully examined. In the present study we measured the expression level of thymidylate synthase (TS), a major target of pemetrexed, reduced folate carrier (RFC) and folylpolyglutamate synthase (FPGS) in lung cancer cell lines and the sensitivity to pemetrexed. The gene expression of TS was significantly correlated with the concentration of pemertrexed for 50% cell survival in 11 non-small cell lung cancer cell lines (r=0.624, p