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2016•Military Medical Science LettersOpen access

CHARACTERISTICS OF VARICELLA ZOSTER (VZV) VIRUS

Vanda Boštíková, Radek Sleha, Miloslav Salavec, Sylva Janovská, Roman Chlíbek, Pavel Blažek, Hana Střítecká, Vladislav Hytych, Kamil Kuča, Irena Hanovcová, Renáta Šošovičková, Jan Smetana, Miroslav Špliňo, Jan Marek, Pavel Boštík

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Abstract

The evolution of varicella zoster virus lasts more than 400 million years.While primates were the original reservoirs of the virus, subsequently VZV started to circulate in human population and humans have been the exclusive hosts for VZV for more than 45 000 years.VZV is a highly contagious and neurotropic herpetic virus a member of the herpesviridae family.Its primary infection results in typical signs of varicella (chickenpox).After that, the virus establishes lifelong latency in trigeminal and dorsal root ganglia.Endogenous viral reactivation, thought to be associated with waning VZV specific T cell mediated imunity, leads to herpes zoster (shingles), especially in older adults and immunocompromised persons (VZV is the only human herpetic virus exhibiting entirely different clinical picture).

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The evolution of varicella zoster virus lasts more than 400 million years.While primates were the original reservoirs of the virus, subsequently VZV started to circulate in human population and humans have been the exclusive hosts for VZV for more than 45 000 years.VZV is a highly contagious and neurotropic herpetic virus a member of the herpesviridae family.Its primary infection results in typical signs of varicella (chickenpox).After that, the virus establishes lifelong latency in trigeminal and dorsal root ganglia.Endogenous viral reactivation, thought to be associated with waning VZV specific T cell mediated imunity, leads to herpes zoster (shingles), especially in older adults and immunocompromised persons (VZV is the only human herpetic virus exhibiting entirely different clinical picture).

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Available abstract

The evolution of varicella zoster virus lasts more than 400 million years.While primates were the original reservoirs of the virus, subsequently VZV started to circulate in human population and humans have been the exclusive hosts for VZV for more than 45 000 years.VZV is a highly contagious and neurotropic herpetic virus a member of the herpesviridae family.Its primary infection results in typical signs of varicella (chickenpox).After that, the virus establishes lifelong latency in trigeminal and dorsal root ganglia.Endogenous viral reactivation, thought to be associated with waning VZV specific T cell mediated imunity, leads to herpes zoster (shingles), especially in older adults and immunocompromised persons (VZV is the only human herpetic virus exhibiting entirely different clinical picture).

Key concepts: Varicella zoster virus, Virology, Chickenpox, Virus, Medicine

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