ELECTROLYTE SALIVA LEVELS IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE BEFORE AND AFTER TREATMENT

Saliva is the first factor in contact with a refluxant, accordingly its composition changes quantitatively and qualitatively. The response to the neutralization function of the saliva is triggered, resulting in poor quality chemical esophageal clearance. Therefore, studying the composition of saliva in patients with gastroesophageal reflux disease (GERD) can be considered as an important early diagnostic marker.Purpose work – Study changes in electrolyte concentration changes in saliva before and after 6 months after treatment.Material and methods. Two groups of patients were examined: control - practically healthy subjects (n = 10) and experimental patients with GERD (n = 15). All patients took morning unstimulated saliva with subsequent determination of electrolyte levels. The treatment was performed for 4 weeks with pantoprazole 40 mg per day.Data processing was carried out using Microsoft Excel. Statistically reliable data was considered at p <0,05.Results and conclusions. The following electrolyte concentrations in saliva were found in patients with GERD prior to treatment: calcium 1.92 ± 0.16 mmol / l, magnesium 0.85 ± 0.03 mmol / L, sodium 63.57 ± 13.07 mmol / l, potassium 13,46 ± 0,67 mmol / liter.Six months after treatment, the levels of salivary electrolytes in patients with GERD were: calcium 2.04 ± 0.07 mmol / l, magnesium 0.96 ± 0.03 mmol / l, sodium 77.81 ± 13.48 mmol / l, potassium 14.63 ± 0.72 mmol / l. Statistically significant fluctuations of levels of calcium, magnesium and sodium have been proved. However, for more reliable data, you need to increase the number of people in both groups.Thus, determining the concentration of salivary electrolytes in patients with GERD maybe both an important screening method for early diagnosis and a reliable assessment of the effectiveness of pharmacotherapy.