2018•Cancer Management and ResearchOpen access

Expression and significance of RRBP1 in esophageal carcinoma

Liang Wang, Ming Wang, Mingyun Zhang, Xingde Li, Zhongcheng Zhu, Haiyan Wang

Abstract

Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma. Materials and methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed. Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues ( P <0.05). Moreover, RRBP1 expression was associated with T stage, lymph node metastasis, and TNM stage in esophageal carcinoma ( P <0.05). Survival analysis revealed that RRBP1, T stage, lymph node metastasis, and TNM stage were significantly associated with patients’ prognosis. Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can serve as a potential biomarker to predict patients’ prognosis. Keywords: RRBP1, prognosis, esophageal carcinoma, survival analysis

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Key concepts: Carcinoma, Expression (computer science), Pathology, Medicine, Internal medicine, Computer science, Programming language