2018•Biochemistry (Moscow)Requires access

Structure and Functions of the Mediator Complex

Egor V. Putlyaev, Airat N. Ibragimov, Lyubov A. Lebedeva, Pavel G Georgiev, Yulii V. Shidlovskii

Abstract

Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Mediator, RNA polymerase II, Chromatin, Cell biology, Transcription (linguistics), Transcription factor, Computational biology, Biology