2018Canadian Medical Association JournalOpen access

Cytisine for smoking cessation

Taleen Karnieg, Xiang Wang

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Abstract

Cytisine, primarily derived from the Cytisus laburnum plant (which inspired the development of varenicline), is a partial agonist of the α4β2 nicotinic acetylcholine receptor responsible for central effects of nicotine.[1][1] Oral cytisine reaches peak concentration two hours postdose[2][2] and is

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What this paper is about

Cytisine, primarily derived from the Cytisus laburnum plant (which inspired the development of varenicline), is a partial agonist of the α4β2 nicotinic acetylcholine receptor responsible for central effects of nicotine.[1][1] Oral cytisine reaches peak concentration two hours postdose[2][2] and is

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Available abstract

Cytisine, primarily derived from the Cytisus laburnum plant (which inspired the development of varenicline), is a partial agonist of the α4β2 nicotinic acetylcholine receptor responsible for central effects of nicotine.[1][1] Oral cytisine reaches peak concentration two hours postdose[2][2] and is

Key concepts: Cytisine, Varenicline, Partial agonist, Nicotine, Nicotinic agonist, Smoking cessation, Pharmacology, Agonist

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