Natural reservoirs of viruses of the genus Hepacivirus, Flaviviridae

HCV is a cause of acute and chronic liver diseases, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Under natural conditions, HCV is able to infect only humans, and only chimpanzees are sensitive to experimental infection. In recent years, viruses genetically related to HCV were discovered in wild mammals (rodents, bats, rabbits), as well as in domestic animals living in close contact with humans (dogs, horses, cows). The hepacivirus genus of the family Flaviviridae, previously represented only by HCV and, presumably, by GBV-B, now includes new related viruses of animals. The results of the study of molecular-genetic and biological properties of the hepaciviruses provide an opportunity to understand the history, evolution, and the origin of HCV. It also opens up the prospect of using HCV homologues of non-primates as a laboratory model for preclinical medical and prophylactic drugs against hepatitis c. It was found that the hepacivirus of horses is the most closely related to HCV among currently known HCV homologues.