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2018•BloodOpen access

Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Geffen Kleinstern, Nicola J. Camp, Lynn R. Goldin, Celine M. Vachon, Claire M. Vajdic, Sílvia de Sanjosé, J. Brice Weinberg, Yolanda Benavente, Delphine Casabonne, Mark Liebow, Alexandra Nieters, Henrik Hjalgrim, Mads Melbye, Bengt Glimelius, Hans‐Olov Adami, Paolo Boffetta, Paul Brennan, Marc Maynadié, James McKay, Pier Luigi Cocco, Tait D. Shanafelt, Timothy G. Call, Aaron D. Norman, Curtis A. Hanson, Dennis P. Robinson, Kari G. Chaffee, Angela Brooks‐Wilson, Alain Monnereau, Jacqueline Clavel, Martha Glenn, Karen Curtin, Lucía Conde, Paige M. Bracci, Lindsay M. Morton, Wendy Cozen, Richard K. Severson, Stephen J. Chanock, John J. Spinelli, James B. Johnston, Nathaniel Rothman, Christine F. Skibola, José F. Leis, Neil E. Kay, Karin E. Smedby, Sonja I. Berndt, James R. Cerhan, Neil E. Caporaso, Susan L. Slager

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Abstract

). In conclusion, our validated PRS was strongly associated with CLL risk, adding information beyond FH. The PRS provides a means of identifying those individuals at greater risk for CLL as well as those at increased risk of MBL, a condition that has potential clinical impact beyond CLL.

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What this paper is about

). In conclusion, our validated PRS was strongly associated with CLL risk, adding information beyond FH. The PRS provides a means of identifying those individuals at greater risk for CLL as well as those at increased risk of MBL, a condition that has potential clinical impact beyond CLL.

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Available abstract

). In conclusion, our validated PRS was strongly associated with CLL risk, adding information beyond FH. The PRS provides a means of identifying those individuals at greater risk for CLL as well as those at increased risk of MBL, a condition that has potential clinical impact beyond CLL.

Key concepts: Lymphocytosis, Chronic lymphocytic leukemia, Medicine, Internal medicine, Leukemia, Oncology, Immunology

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Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis — Research Paper | ScholarLens