2018•Unpublished venueRequires access
Antidiabetic Effects of Essential Oils of some Selected Medicinal Lamiaceae Plants from Yemen against α-Glucosidase Enzyme
Ya’ni Aa, Eldahshan Oa, Hassan Sa, Elwan Za, Ibrahim Hm
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Abstract
Essential oils of four species used in traditional medicine in Bani Matar District in Yemen, family Lamiaceae were assessed chemically and biologically for their antidiabetic activity; Leucas inflata, Marrubium vulgare, Salvia schimper and Origanum majorana. The results indicated that Salvia schimperi essential oil exhibited the most dosedependent inhibitory activity against α-gucosidase enzyme with IC50 of 14.26 μL (nearly similar to acarbose of IC50 12.87 μL) followed by Marrubium vulgare oil with IC50 value at 35.47 μL. Leucas inflata essential oil exhibited weak dose-dependent inhibitory activity against α-glucosidase enzyme with IC50 of 159.66 μL and no effect was observed with Origanum majorana. The antidiabetic activities observed was due to the presence of compounds such as caryophyllene, bisabolol and farnesene. Our results obviously cleared that essential oils of Salvia schimperi and Marrubium vulgare exerted promising antidiabetic effects so; we recommended using such as oils as futural natural antidiabetic.