Isolated, premature ventricular complex–induced right ventricular dysfunction mimicking arrhythmogenic right ventricular cardiomyopathy

Key Teaching Points•The present case shows a new clinical entity consisting of isolated right ventricle (RV) cardiomyopathy induced by frequent premature ventricular contractions (PVCs), mimicking arrhythmogenic right ventricular cardiomyopathy (ARVC).•The diagnosis of pure PVC-induced RV cardiomyopathy can fully overlap with that of ARVC. This new entity may fulfill enough Task Force criteria to be misdiagnosed as a “definite” ARVC.•Pure PVC-induced RV cardiomyopathy should be considered in cases of RV systolic dysfunction and a high burden of PVCs arising from the RV, especially for those located in the free wall. Marked mechanical and electrical dyssynchrony of the RV are postulated as likely mechanisms for this entity.•Successful PVC ablation in cases of pure PVC-induced RV cardiomyopathy results in complete normalization of electrocardiographic and echocardiographic parameters that mistakenly fulfilled the Task Force criteria for ARVC. •The present case shows a new clinical entity consisting of isolated right ventricle (RV) cardiomyopathy induced by frequent premature ventricular contractions (PVCs), mimicking arrhythmogenic right ventricular cardiomyopathy (ARVC).•The diagnosis of pure PVC-induced RV cardiomyopathy can fully overlap with that of ARVC. This new entity may fulfill enough Task Force criteria to be misdiagnosed as a “definite” ARVC.•Pure PVC-induced RV cardiomyopathy should be considered in cases of RV systolic dysfunction and a high burden of PVCs arising from the RV, especially for those located in the free wall. Marked mechanical and electrical dyssynchrony of the RV are postulated as likely mechanisms for this entity.•Successful PVC ablation in cases of pure PVC-induced RV cardiomyopathy results in complete normalization of electrocardiographic and echocardiographic parameters that mistakenly fulfilled the Task Force criteria for ARVC.