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2018•Neurology neuropsychiatry PsychosomaticsOpen access

Neuromyelitis optica spectrum disorders in pediatric patients

Yu. V. Tokareva, А. С. Котов, М. В. Пантелеева, М. С. Бунак

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Abstract

Neuromyelitis optica spectrum disorders (NMOSDs) is an inflammatory demyelinating disease of the central nervous system with a selective injury of the optic nerves and spinal cord. The formation of neuromyelitis optica ((NMO)-IgG autoantibodies against the cell membrane water channel protein aquaporin 4 (AQP4) underlies the pathogenesis of the disease. The article describes the clinical presentation of the disease in pediatric patients followed up by the authors. It presents the criteria for diagnosing NMOSDs and their therapy regimens.

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Neuromyelitis optica spectrum disorders (NMOSDs) is an inflammatory demyelinating disease of the central nervous system with a selective injury of the optic nerves and spinal cord. The formation of neuromyelitis optica ((NMO)-IgG autoantibodies against the cell membrane water channel protein aquaporin 4 (AQP4) underlies the pathogenesis of the disease. The article describes the clinical presentation of the disease in pediatric patients followed up by the authors. It presents the criteria for diagnosing NMOSDs and their therapy regimens.

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Available abstract

Neuromyelitis optica spectrum disorders (NMOSDs) is an inflammatory demyelinating disease of the central nervous system with a selective injury of the optic nerves and spinal cord. The formation of neuromyelitis optica ((NMO)-IgG autoantibodies against the cell membrane water channel protein aquaporin 4 (AQP4) underlies the pathogenesis of the disease. The article describes the clinical presentation of the disease in pediatric patients followed up by the authors. It presents the criteria for diagnosing NMOSDs and their therapy regimens.

Key concepts: Neuromyelitis optica, Medicine, Aquaporin 4, Disease, Autoantibody, Demyelinating Disorder, Demyelinating disease, Central nervous system

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