2017•S S Korsakov Journal of Neurology and PsychiatryRequires access

Seven principles in the treatment of vestibular vertigo and results of the study of VIRTUOSO

М. В. Замерград, В. А. Парфенов, Matsnev Ei, S. V. Morozova, O. A. Melnikov, Sigaleva Ee, Л. М. Антоненко

Abstract

This article reports the results of the international post-marketing observational program VIRTUOSO aimed at the evaluation of the efficacy of betahistine dihydrochloride at the dose of 48 mg/day for 1-2 months in patients with paroxysmal vertigo of various origins. The clinical response was rated as good, very good or excellent in 74.1% of the patients (p<0.001). Monthly vertigo attack frequency with betahistine decreased in average from 8.0 to 3.0 (p<0.001). Vertigo attack frequency further decreased during the 2-month follow-up after the end of betahistine treatment. No serious adverse effects of betahistine have been reported.

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Key concepts: Betahistine, Medicine, Vertigo, Observational study, Adverse effect, Vestibular system, Audiology, Tinnitus