2018•BIO-PROTOCOLOpen access

Barnes Maze Procedure for Spatial Learning and Memory in Mice

Matthew W. Pitts

Abstract

The Barnes maze is a dry-land based rodent behavioral paradigm for assessing spatial learning and memory that was originally developed by its namesake, Carol Barnes. It represents a well-established alternative to the more popular Morris Water maze and offers the advantage of being free from the potentially confounding influence of swimming behavior. Herein, the Barnes maze experimental setup and corresponding procedures for testing and analysis in mice are described in detail.

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Key concepts: Morris water navigation task, Spatial learning, Barnes maze, Water maze, Dry land, Rodent, Psychology, Cognitive psychology