The age-regulated zinc finger factor ZNF367 is a new modulator of embryonic neurogenesis

Abstract Global population aging is one of the major social and economic challenges of contemporary society. During aging the progressive decline in physiological functions has serious consequences for all organs including brain. The age-related incidence of neurodegenerative diseases coincides with the sharp decline of the amount and functionality of adult neural stem cells. Recently, we identified a short list of brain age-regulated genes by means of next-generation sequencing. Among them znf367 codes for a transcription factor that represents a central node in gene coregulation networks during aging but its function, in the central nervous system (CNS), is completely unknown. As proof of concept we analyzed the role of znf367 during neurogenesis. By means of a gene loss of function approach limited to the CNS, we suggested that znf367 might act as a key controller of the neuroblasts cell cycle, particularly in the progression of mitosis and spindle check-point. Using a candidate gene approach, based on a weighted-gene co-expression network analysis, we suggested possible targets of znf367 such as fancd2 and ska3 . The age-related decline of znf36 7 well correlated with its role during embryonic neurogenesis opening new lines of investigation to improved maintenance and even repair of neuronal function.